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Journal Publications

- Claude Bernard -

“The joy of discovery is certainly the liveliest that the mind of man can ever feel”




Journal of Biological Chemistry 276(9): 6656-65. Kinoshita Y, Jarell AD, Flaman JM, Foltz G, Schuster J, Sopher BL, Irvin DK, Kanning K, Kornblum HI, Nelson PS, Hieter P, Morrison RS. Pescadillo, a novel cell cycle regulatory protein abnormally expressed in malignant cells. 

Journal of Comparative Neurology 436(2): 167-81. Irvin DK, Zurcher SD, Nguyen T, Weinmaster G, Kornblum HI. Expression patterns of Notch1, Notch 2, and Notch 3 suggest multiple functional roles for the Notch-DSL signaling system during brain development. 


Journal of Neuroscience23(3):748-57.Dhaka A, Costa RM, Hu H, Irvin DK, Patel A, Kornblum HI, Silva AJ, O'Dell TJ, Colicelli J. The RAS effector RIN1 modulates the formation of aversive memories


Developmental Neuroscience 25(2-4):162-72. Irvin DK, Dhaka A, Hicks C, Weinmaster G, Kornblum HI. Extrinsic and intrinsic factors governing cell fate in cortical progenitor cultures. 


Developmental Biology 264(2): 309-22.Easterday MC, Dougherty JD, Jackson RL, Ou J, Nakano I, Paucar AA, RoobiniB, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI.Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. 


Journal of Neuroscience Research 75(3): 330-47. Irvin DK, Nakano I, Paucar AA, Kornblum HI. Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggests multiple functional roles in progenitors and differentiated cells.

Current Stem Cell Research & Therapy. Irvin DK, Yuan X, Tunici P, Yu JS. Neural Stem Cells – A Promising Potential Therapy for Brain Tumors. 


Neurosurgical Focus 20(4) E27, 2006. Tunici P, Irvin DK, Liu G, Yuan X, Zhaohui Z, Ng H, Yu J, Brain Tumor Stem Cells: New Targets for Clinical Treatments. 


Experimental Cell Research. Apr 1; 313(6):1172-80 Andersson E, Irvin DK, Ahlsiö J Parmar M. Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and 
progenitor cells. 


Molecular Cancer. Dec 2; 5:67. Liu G, Yuan X, Zeng Z, Tunici P, Ng H, Abdulkadir IR, Lu L, Irvin DK, Black KL, Yu JS. Analysis of gene expression and chemo resistance of CD133+ cancer stem cells in glioblastoma. 



Molecular Cancer. Mar 14; 6:22. Hu J, Yuan X, Ko MK, Yin D, Sacapano MR, Wang X, Konda BM, Espinoza A, Prosolovich K, Ong JM, Irvin DK, Black KL. Calcium-activated potassium channels mediated blood-brain tumor barrier opening in a rat metastatic brain tumor model. 

Stem Cells Jul;25(7):1645-53*Ghods-Jourabchi A, *Irvin DK, Gentao Liu G, Abdulkadir I, Yuan X, Tunici P, Wachsmann-Hogi S, Konda B, Black K, Yu J, Spheres Isolated from 9LGliosarcoma Rat Cell Line Possess Chemo resistant and Aggressive Cancer Stem-Like Cells. 


Clinical Cancer Research, Jun15;14(12):4002-9. Yin D, Wang X, Konda B, Ong J, Hu J, Sacapano M, Ko M, Espinoza A, Irvin DK, Shu Y, Black K. Increase in Brain Tumor Permeability in Glioma-bearing Rats with Nitric Oxide Donors. 


Neurobiology of Disease. Jun; 30(3):343-52 (Selected as Cover Article). Irvin DK, Thompson L, Kirik D, Björklund A In Vivo Gene Delivery to Endogenous Striatal Progenitors Generated by a 6-hydroxydopamine Lesion of the Nigrostriatal Dopamine Pathway. 


Brain Research, Sept. 1230:290-302.Black K, Yin D, Ong J, Hu J, Konda B, Wang X, Ko M, Bayan J, Sacapano M, Espinoza A, Irvin DK, Shu Y. Phosphodiesterase 5 Inhibitors Enhance Tumor Permeability and Efficacy of Chemotherapy in a Rat Brain Tumor Model. 


Brain Research Aug 28; 1227:198-206 (Selected as Cover Article).Black K, Yin D, Konda B, Wang X, Hu J, Ko M, Bayan J, Sacapano M, Espinoza A, Ong J, Irvin DK, Shu Y, Different Effects of KCa and KATP Agonists on Brain Tumor Permeability between Syngeneic and Allogeneic Rat Models. 


Cancer Research, Jul 15;68 (14):5955-64. Wheeler C, Black K, Liu G, Wagenberg M, Zhang X, Pepkowitz S, Goldfinger D,Ng H, Irvin DK, Yu J. Vaccination with tumor lysate-pulsed dendritic cells elicitscor related immune and clinical response magnitudes in patients with glioblastoma multiforme. 


PlosOne, Jun 7;5(6): e10974. Irvin DK, Jouanneau E, Duvall G, Zhang X, Zhai y, Sarayba D, Seksenyan A, Panwar A, Black KL, Wheeler CJ. T cell activity promotes stem-like properties, but not malignancy, in gliomas.


Journal of Neurosurgery Patil C, Yi A, Elramsisy A, Hu J, Mukherjee D, Irvin D, Yu J, Bannykh S, Black K, Nuño M. Prognosis of Patients with Multifocal Glioblastoma: A Case-Controlled Study. 


June; Cancer Immunology,Immunotherapy. Jouanneau, E., Black, K.L., Veiga, L., Goverdhana, S., Gragg, A., Zandian, M., Zhai, Y., Zhang, X-x., Mardiros, A., Wang, H.-Q., Panwar, A., Irvin, D., and Wheeler, C. J. Intrinsically de-sialylated CD103(+) CD8 T cells mediate beneficial anti-glioma immune responses.

July; Journal of Neurology & Neurophysiology. Wheeler C, Wu H, Sarayba D, Siegel E, Thomas 
D, Andres E, Thompson K, Black KL, Pechnick P, Irvin D, T-lymphocytes influence behavioral deficits in the 6-OHDA unilateral lesion model for Parkinson’s disease. 


In Submission, PlosOne. Miyamoto S, Retana L, Soobiah V, Rentsendorj A, Phuphanich S, Rudnick J, Black K, Irvin DK, Temozolomide promotes immunoresistance in surviving glioma cells via Stat3 activation and subsequent B7-H1 and B7-H4 upregulation. 


Book Chapter: The Textbook of Nano neurosurgery, Edited by: Babak Kateb & John D. Heiss, Immune Based Targeting in Cancer; Irvin DK, Chirag Patil, Keith Black. ISBN-10: 1439849412.

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